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Medientyp:
E-Artikel
Titel:
Long noncoding RNA: a dazzling dancer in tumor immune microenvironment
Beteiligte:
Zhang, Yalu;
Liu, Qiaofei;
Liao, Quan
Erschienen:
Springer Science and Business Media LLC, 2020
Erschienen in:Journal of Experimental & Clinical Cancer Research
Sprache:
Englisch
DOI:
10.1186/s13046-020-01727-3
ISSN:
1756-9966
Entstehung:
Anmerkungen:
Beschreibung:
<jats:title>Abstract</jats:title><jats:p>Long noncoding RNAs (lncRNAs) are a class of endogenous, non-protein coding RNAs that are highly linked to various cellular functions and pathological process. Emerging evidence indicates that lncRNAs participate in crosstalk between tumor and stroma, and reprogramming of tumor immune microenvironment (TIME). TIME possesses distinct populations of myeloid cells and lymphocytes to influence the immune escape of cancer, the response to immunotherapy, and the survival of patients. However, hitherto, a comprehensive review aiming at relationship between lncRNAs and TIME is missing. In this review, we focus on the functional roles and molecular mechanisms of lncRNAs within the TIME. Furthermore, we discussed the potential immunotherapeutic strategies based on lncRNAs and their limitations.</jats:p>