Hassan, Wageeh A.;
Darweesh, Alaa Eldin M.;
Abdel-Rahman, Ahmed A.;
Ahmad, Hossam Eddin Khalifa;
Hassaan, Shehab H.;
Noaman, Mostafa M.;
Fahmy, Iman F. G.
P300 cognitive assessment in patients with first-episode psychosis: a prospective case-control study
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Media type:
E-Article
Title:
P300 cognitive assessment in patients with first-episode psychosis: a prospective case-control study
Contributor:
Hassan, Wageeh A.;
Darweesh, Alaa Eldin M.;
Abdel-Rahman, Ahmed A.;
Ahmad, Hossam Eddin Khalifa;
Hassaan, Shehab H.;
Noaman, Mostafa M.;
Fahmy, Iman F. G.
Published:
Springer Science and Business Media LLC, 2020
Published in:
Middle East Current Psychiatry, 27 (2020) 1
Description:
<jats:title>Abstract</jats:title><jats:sec>
<jats:title>Background</jats:title>
<jats:p>Several studies using event-related potential (ERP) methods have reported a relationship between the cognitive dysfunction of patients with psychosis and P300 latency and amplitude. P300 follow-up studies in patients with schizophrenia receiving antipsychotic treatment revealed that the P300 amplitudes were increased while other studies showed limited changes in the P300 amplitude even after antipsychotics use.</jats:p>
</jats:sec><jats:sec>
<jats:title>Results</jats:title>
<jats:p>We found that at the first presentation, all patients’ groups have significantly lower amplitude and more prolonged latency of P300 than controls. All the first-episode psychosis patients showed a significant improvement of P300 amplitude mean scores after 1 year, but with no significant change in the P300 latency. There was an inverse correlation between the patients’ PANSS scores and their P300 latency and amplitude values.</jats:p>
</jats:sec><jats:sec>
<jats:title>Conclusion</jats:title>
<jats:p>P300 amplitude and latency might be of clinical value in the evaluation of cognitive functions in the first-episode psychosis patients. The abnormalities in P300 may be improved with continuous control of psychotic symptoms with psychotropic medications.</jats:p>
</jats:sec>