Hassan, Wageeh A.;
Darweesh, Alaa Eldin M.;
Abdel-Rahman, Ahmed A.;
Ahmad, Hossam Eddin Khalifa;
Hassaan, Shehab H.;
Noaman, Mostafa M.;
Fahmy, Iman F. G.
P300 cognitive assessment in patients with first-episode psychosis: a prospective case-control study
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Medientyp:
E-Artikel
Titel:
P300 cognitive assessment in patients with first-episode psychosis: a prospective case-control study
Beteiligte:
Hassan, Wageeh A.;
Darweesh, Alaa Eldin M.;
Abdel-Rahman, Ahmed A.;
Ahmad, Hossam Eddin Khalifa;
Hassaan, Shehab H.;
Noaman, Mostafa M.;
Fahmy, Iman F. G.
Erschienen:
Springer Science and Business Media LLC, 2020
Erschienen in:
Middle East Current Psychiatry, 27 (2020) 1
Beschreibung:
AbstractBackgroundSeveral studies using event-related potential (ERP) methods have reported a relationship between the cognitive dysfunction of patients with psychosis and P300 latency and amplitude. P300 follow-up studies in patients with schizophrenia receiving antipsychotic treatment revealed that the P300 amplitudes were increased while other studies showed limited changes in the P300 amplitude even after antipsychotics use.ResultsWe found that at the first presentation, all patients’ groups have significantly lower amplitude and more prolonged latency of P300 than controls. All the first-episode psychosis patients showed a significant improvement of P300 amplitude mean scores after 1 year, but with no significant change in the P300 latency. There was an inverse correlation between the patients’ PANSS scores and their P300 latency and amplitude values.ConclusionP300 amplitude and latency might be of clinical value in the evaluation of cognitive functions in the first-episode psychosis patients. The abnormalities in P300 may be improved with continuous control of psychotic symptoms with psychotropic medications.