• Media type: E-Article
  • Title: MicroRNA regulation of T‐cell differentiation and function
  • Contributor: Jeker, Lukas T.; Bluestone, Jeffrey A.
  • imprint: Wiley, 2013
  • Published in: Immunological Reviews
  • Language: English
  • DOI: 10.1111/imr.12061
  • ISSN: 0105-2896; 1600-065X
  • Origination:
  • Footnote:
  • Description: <jats:title>Summary</jats:title><jats:p>Micro<jats:styled-content style="fixed-case">RNA</jats:styled-content>s (mi<jats:styled-content style="fixed-case">RNA</jats:styled-content>s) are emerging as key controllers of T‐cell differentiation and function. Their expression is dynamically regulated by extracellular signals such as costimulation and cytokine signals. mi<jats:styled-content style="fixed-case">RNA</jats:styled-content>s set thresholds for gene expression and optimize protein concentrations of genetic networks. Absence of individual mi<jats:styled-content style="fixed-case">RNA</jats:styled-content>s can lead to severe immune dysfunction. In this study, we review emerging principles and provide examples of important functions exerted by mi<jats:styled-content style="fixed-case">RNA</jats:styled-content>s. Although our understanding of mi<jats:styled-content style="fixed-case">RNA</jats:styled-content> function in T‐cell differentiation is still rudimentary, the available evidence leaves no doubt that these small post‐transcriptional regulators are indispensable for proper functioning of the immune system.</jats:p>