Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
Medientyp:
E-Artikel
Titel:
MicroRNA regulation of T‐cell differentiation and function
Beteiligte:
Jeker, Lukas T.;
Bluestone, Jeffrey A.
Erschienen:
Wiley, 2013
Erschienen in:Immunological Reviews
Sprache:
Englisch
DOI:
10.1111/imr.12061
ISSN:
0105-2896;
1600-065X
Entstehung:
Anmerkungen:
Beschreibung:
<jats:title>Summary</jats:title><jats:p>Micro<jats:styled-content style="fixed-case">RNA</jats:styled-content>s (mi<jats:styled-content style="fixed-case">RNA</jats:styled-content>s) are emerging as key controllers of T‐cell differentiation and function. Their expression is dynamically regulated by extracellular signals such as costimulation and cytokine signals. mi<jats:styled-content style="fixed-case">RNA</jats:styled-content>s set thresholds for gene expression and optimize protein concentrations of genetic networks. Absence of individual mi<jats:styled-content style="fixed-case">RNA</jats:styled-content>s can lead to severe immune dysfunction. In this study, we review emerging principles and provide examples of important functions exerted by mi<jats:styled-content style="fixed-case">RNA</jats:styled-content>s. Although our understanding of mi<jats:styled-content style="fixed-case">RNA</jats:styled-content> function in T‐cell differentiation is still rudimentary, the available evidence leaves no doubt that these small post‐transcriptional regulators are indispensable for proper functioning of the immune system.</jats:p>