Dos Santos, Daniela Cristina;
Saraiva Camara, Niels Olsen;
David, Daisa Silva Ribeiro;
Malheiros, Denise Maria Avancini Costa
Expression patterns of CD56+ and CD16+ cells in renal transplant biopsies with acute rejection: Associations with microcirculation injuries and graft survival
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Media type:
E-Article
Title:
Expression patterns of CD56+ and CD16+ cells in renal transplant biopsies with acute rejection: Associations with microcirculation injuries and graft survival
Contributor:
Dos Santos, Daniela Cristina;
Saraiva Camara, Niels Olsen;
David, Daisa Silva Ribeiro;
Malheiros, Denise Maria Avancini Costa
imprint:
Wiley, 2017
Published in:
Nephrology, 22 (2017) 12, Seite 993-1001
Description:
<jats:title>ABSTRACT</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>The study investigated whether immunohistochemical features of interstitial and glomerular CD56 and CD16 infiltrates – NK cells markers – could be associated with microcirculation injury scores – peritubular capillaritis (ptc) and glomerulitis (g) – and graft survival.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>The research analyzed the immunohistochemical pattern of CD56 and CD16 in interstitial and glomerular compartments of biopsies for‐cause biopsies from 59 recipients diagnosed with acute rejection (mea<jats:italic>n =</jats:italic> 135.5 days post‐transplant).</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Interstitial CD56+ cells had an increased expression for glomerulitis (g ≥ 1) (<jats:italic>P =</jats:italic> 0.02) and peritubular capillaritis (ptc ≥ 2) (<jats:italic>P =</jats:italic> 0.003) presence. It was noted that interstitial CD56 + cells with mean above 0.56 cells/mm<jats:sup>2</jats:sup> had worse allograft survival. CD56+ cells in the interstitial compartment with mean less than or equal to 0.56cells/mm<jats:sup>2</jats:sup> was related with absence or mild peritubular capillaritis (<jats:italic>P =</jats:italic> 0.012) and mean above 0.56 cells/mm<jats:sup>2</jats:sup>, respectively, with glomerulitis (<jats:italic>P =</jats:italic> 0.002) presence. Interstitial CD16 cells showed greater positive results in relation to peritubular capillaritis (<jats:italic>P =</jats:italic> 0.0001) cases. Similarly, it was observed that glomerular CD16+ cells had higher positive results in glomerulitis (<jats:italic>P =</jats:italic> 0.009) presence.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The study findings showed that CD56+ cell infiltrated in the interstitial compartment was significantly associated with microcirculation injury scores, especially the glomerulitis, and graft survival.</jats:p></jats:sec>