Dos Santos, Daniela Cristina;
Saraiva Camara, Niels Olsen;
David, Daisa Silva Ribeiro;
Malheiros, Denise Maria Avancini Costa
Expression patterns of CD56+ and CD16+ cells in renal transplant biopsies with acute rejection: Associations with microcirculation injuries and graft survival
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Medientyp:
E-Artikel
Titel:
Expression patterns of CD56+ and CD16+ cells in renal transplant biopsies with acute rejection: Associations with microcirculation injuries and graft survival
Beteiligte:
Dos Santos, Daniela Cristina;
Saraiva Camara, Niels Olsen;
David, Daisa Silva Ribeiro;
Malheiros, Denise Maria Avancini Costa
Erschienen:
Wiley, 2017
Erschienen in:
Nephrology, 22 (2017) 12, Seite 993-1001
Sprache:
Englisch
DOI:
10.1111/nep.12897
ISSN:
1320-5358;
1440-1797
Entstehung:
Anmerkungen:
Beschreibung:
ABSTRACTBackgroundThe study investigated whether immunohistochemical features of interstitial and glomerular CD56 and CD16 infiltrates – NK cells markers – could be associated with microcirculation injury scores – peritubular capillaritis (ptc) and glomerulitis (g) – and graft survival.MethodsThe research analyzed the immunohistochemical pattern of CD56 and CD16 in interstitial and glomerular compartments of biopsies for‐cause biopsies from 59 recipients diagnosed with acute rejection (mean = 135.5 days post‐transplant).ResultsInterstitial CD56+ cells had an increased expression for glomerulitis (g ≥ 1) (P = 0.02) and peritubular capillaritis (ptc ≥ 2) (P = 0.003) presence. It was noted that interstitial CD56 + cells with mean above 0.56 cells/mm2 had worse allograft survival. CD56+ cells in the interstitial compartment with mean less than or equal to 0.56cells/mm2 was related with absence or mild peritubular capillaritis (P = 0.012) and mean above 0.56 cells/mm2, respectively, with glomerulitis (P = 0.002) presence. Interstitial CD16 cells showed greater positive results in relation to peritubular capillaritis (P = 0.0001) cases. Similarly, it was observed that glomerular CD16+ cells had higher positive results in glomerulitis (P = 0.009) presence.ConclusionsThe study findings showed that CD56+ cell infiltrated in the interstitial compartment was significantly associated with microcirculation injury scores, especially the glomerulitis, and graft survival.