• Media type: E-Article
  • Title: A Marine Natural Product Inhibitor of Kinesin Motors
  • Contributor: Sakowicz, Roman; Berdelis, Michael S.; Ray, Krishanu; Blackburn, Christine L.; Hopmann, Cordula; Faulkner, D. John; Goldstein, Lawrence S. B.
  • Published: American Association for the Advancement of Science (AAAS), 1998
  • Published in: Science, 280 (1998) 5361, Seite 292-295
  • Language: English
  • DOI: 10.1126/science.280.5361.292
  • ISSN: 0036-8075; 1095-9203
  • Origination:
  • Footnote:
  • Description: Members of the kinesin superfamily of motor proteins are essential for mitotic and meiotic spindle organization, chromosome segregation, organelle and vesicle transport, and many other processes that require microtubule-based transport. A compound, adociasulfate-2, was isolated from a marine sponge, Haliclona (also known as Adocia ) species, that inhibited kinesin activity by targeting its motor domain and mimicking the activity of the microtubule. Thus, the kinesin-microtubule interaction site could be a useful target for small molecule modulators, and adociasulfate-2 should serve as an archetype for specific inhibitors of kinesin functions.