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Medientyp:
E-Artikel
Titel:
A Marine Natural Product Inhibitor of Kinesin Motors
Beteiligte:
Sakowicz, Roman;
Berdelis, Michael S.;
Ray, Krishanu;
Blackburn, Christine L.;
Hopmann, Cordula;
Faulkner, D. John;
Goldstein, Lawrence S. B.
Erschienen:
American Association for the Advancement of Science (AAAS), 1998
Erschienen in:
Science, 280 (1998) 5361, Seite 292-295
Beschreibung:
<jats:p>
Members of the kinesin superfamily of motor proteins are essential for mitotic and meiotic spindle organization, chromosome segregation, organelle and vesicle transport, and many other processes that require microtubule-based transport. A compound, adociasulfate-2, was isolated from a marine sponge,
<jats:italic>Haliclona</jats:italic>
(also known as
<jats:italic>Adocia</jats:italic>
) species, that inhibited kinesin activity by targeting its motor domain and mimicking the activity of the microtubule. Thus, the kinesin-microtubule interaction site could be a useful target for small molecule modulators, and adociasulfate-2 should serve as an archetype for specific inhibitors of kinesin functions.
</jats:p>