• Media type: E-Article
  • Title: Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors
  • Contributor: Young, Matthew D.; Mitchell, Thomas J.; Vieira Braga, Felipe A.; Tran, Maxine G. B.; Stewart, Benjamin J.; Ferdinand, John R.; Collord, Grace; Botting, Rachel A.; Popescu, Dorin-Mirel; Loudon, Kevin W.; Vento-Tormo, Roser; Stephenson, Emily; Cagan, Alex; Farndon, Sarah J.; Del Castillo Velasco-Herrera, Martin; Guzzo, Charlotte; Richoz, Nathan; Mamanova, Lira; Aho, Tevita; Armitage, James N.; Riddick, Antony C. P.; Mushtaq, Imran; Farrell, Stephen; Rampling, Dyanne; [...]
  • Published: American Association for the Advancement of Science (AAAS), 2018
  • Published in: Science, 361 (2018) 6402, Seite 594-599
  • Language: English
  • DOI: 10.1126/science.aat1699
  • ISSN: 0036-8075; 1095-9203
  • Origination:
  • Footnote:
  • Description: Pediatric and adult kidney tumors differ Understanding tumor origins and the similarities and differences between organ-specific cancers is important for determining treatment options. Young et al. generated more than 72,000 single-cell transcriptomes from healthy and cancerous human kidneys. From these data, they determined that Wilms tumor, a pediatric kidney cancer, originates from aberrant fetal cells, whereas adult kidney cancers are likely derived from a specific subtype of proximal convoluted tubular cell. Science , this issue p. 594