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Media type:
E-Article
Title:
Contrasting Modes of New World Arenavirus Neutralization by Immunization-Elicited Monoclonal Antibodies
Contributor:
Ng, Weng M.;
Sahin, Mehmet;
Krumm, Stefanie A.;
Seow, Jeffrey;
Zeltina, Antra;
Harlos, Karl;
Paesen, Guido C.;
Pinschewer, Daniel D.;
Doores, Katie J.;
Bowden, Thomas A.
Published:
American Society for Microbiology, 2022
Published in:
mBio, 13 (2022) 2
Language:
English
DOI:
10.1128/mbio.02650-21
ISSN:
2150-7511
Origination:
Footnote:
Description:
<jats:p>The GP1 subcomponent of the New World arenavirus GP is a primary target of the neutralizing antibody response, which has been shown to be effective in the prevention and treatment of infection. Here, we characterize the structural basis of the antibody-mediated immune response that arises from immunization of mice against Junín virus and Machupo virus, two rodent-borne zoonotic New World arenaviruses.</jats:p>