• Medientyp: E-Artikel
  • Titel: Contrasting Modes of New World Arenavirus Neutralization by Immunization-Elicited Monoclonal Antibodies
  • Beteiligte: Ng, Weng M.; Sahin, Mehmet; Krumm, Stefanie A.; Seow, Jeffrey; Zeltina, Antra; Harlos, Karl; Paesen, Guido C.; Pinschewer, Daniel D.; Doores, Katie J.; Bowden, Thomas A.
  • Erschienen: American Society for Microbiology, 2022
  • Erschienen in: mBio, 13 (2022) 2
  • Sprache: Englisch
  • DOI: 10.1128/mbio.02650-21
  • ISSN: 2150-7511
  • Entstehung:
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  • Beschreibung: <jats:p>The GP1 subcomponent of the New World arenavirus GP is a primary target of the neutralizing antibody response, which has been shown to be effective in the prevention and treatment of infection. Here, we characterize the structural basis of the antibody-mediated immune response that arises from immunization of mice against Junín virus and Machupo virus, two rodent-borne zoonotic New World arenaviruses.</jats:p>
  • Zugangsstatus: Freier Zugang