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Media type:
E-Article
Title:
Trophoblast development
Contributor:
Pfeffer, Peter L;
Pearton, David J
imprint:
Bioscientifica, 2012
Published in:REPRODUCTION
Language:
Not determined
DOI:
10.1530/rep-11-0374
ISSN:
1470-1626;
1741-7899
Origination:
Footnote:
Description:
<jats:p>This review summarises current knowledge about the specification, commitment and maintenance of the trophoblast lineage in mice and cattle. Results from gene expression studies,<jats:italic>in vivo</jats:italic>loss-of-function models and<jats:italic>in vitro</jats:italic>systems using trophoblast and embryonic stem cells have been assimilated into a model seeking to explain trophoblast ontogeny via gene regulatory networks. While trophoblast differentiation is quite distinct between cattle and mice, as would be expected from their different modes of implantation, recent studies have demonstrated that differences arise much earlier during trophoblast development.</jats:p>