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Medientyp:
E-Artikel
Titel:
Trophoblast development
Beteiligte:
Pfeffer, Peter L;
Pearton, David J
Erschienen:
Bioscientifica, 2012
Erschienen in:REPRODUCTION
Sprache:
Nicht zu entscheiden
DOI:
10.1530/rep-11-0374
ISSN:
1470-1626;
1741-7899
Entstehung:
Anmerkungen:
Beschreibung:
<jats:p>This review summarises current knowledge about the specification, commitment and maintenance of the trophoblast lineage in mice and cattle. Results from gene expression studies,<jats:italic>in vivo</jats:italic>loss-of-function models and<jats:italic>in vitro</jats:italic>systems using trophoblast and embryonic stem cells have been assimilated into a model seeking to explain trophoblast ontogeny via gene regulatory networks. While trophoblast differentiation is quite distinct between cattle and mice, as would be expected from their different modes of implantation, recent studies have demonstrated that differences arise much earlier during trophoblast development.</jats:p>