Beschreibung:
Wnt/β-catenin-dependent signaling pathway is indispensible for cardiac development, becoming quiescent in the normal adult heart, and re-activated in both regenerative responses post-injury and in cardiac hypertrophy and failure. Many studies have demonstrated the effect of its main nuclear effector- Transcription factor 7-like 2 (TCF7L2) in influencing chromatin landscapes in different malignancies. However, despite being widely studied in the heart, there was little or no evidence for the role of Wnt-TCF7L2 in directly governing cardiac chromatin homeostasis. To address this direct functi...