Management of acute exacerbation of idiopathic pulmonary fibrosis in specialised and non-specialised ILD centres around the world

Medientyp: E-Artikel

Titel: Management of acute exacerbation of idiopathic pulmonary fibrosis in specialised and non-specialised ILD centres around the world

Beteiligte: Polke, Markus [Verfasser:in]; Kondoh, Yasuhiro [Verfasser:in]; Wijsenbeek, Marlies [Verfasser:in]; Cottin, Vincent [Verfasser:in]; Walsh, Simon L. F. [Verfasser:in]; Collard, Harold R. [Verfasser:in]; Chaudhuri, Nazia [Verfasser:in]; Avdeev, Sergey [Verfasser:in]; Behr, Jürgen [Verfasser:in]; Calligaro, Gregory [Verfasser:in]; Corte, Tamera J. [Verfasser:in]; Flaherty, Kevin [Verfasser:in]; Funke-Chambour, Manuela [Verfasser:in]; Kolb, Martin [Verfasser:in]; Krisam, Johannes [Verfasser:in]; Maher, Toby M. [Verfasser:in]; Molina-Molina, Maria [Verfasser:in]; Morais, Antonio [Verfasser:in]; Moor, Catharina C. [Verfasser:in]; Morisset, Julie [Verfasser:in]; Pereira, Carlos [Verfasser:in]; Quadrelli, Silvia [Verfasser:in]; Selman, Moises [Verfasser:in]; Tzouvelekis, Argyrios [Verfasser:in]; Valenzuela, Claudia [Verfasser:in]; Vancheri, Carlo [Verfasser:in]; Vicens-Zygmunt, Vanesa [Verfasser:in]; Wälscher, Julia [Verfasser:in]; Wuyts, Wim [Verfasser:in]; Bendstrup, Elisabeth [Verfasser:in]; Kreuter, Michael [Verfasser:in]

Erschienen: 27 September 2021

Sprache: Englisch

DOI: 10.3389/fmed.2021.699644

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Beschreibung: Background: Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is a severe complication associated with a high mortality. However, evidence and guidance on management is sparse. The aim of this international survey was to assess differences in prevention, diagnostic and treatment strategies for AE-IPF in specialised and non-specialised ILD centres worldwide.Material and Methods: Pulmonologists working in specialised and non-specialised ILD centres were invited to participate in a survey designed by an international expert panel. Responses were evaluated in respect to the physicians' institutions.Results: Three hundred and two (65%) of the respondents worked in a specialised ILD centre, 134 (29%) in a non-specialised pulmonology centre. Similarities were frequent with regards to diagnostic methods including radiology and screening for infection, treatment with corticosteroids, use of high-flow oxygen and non-invasive ventilation in critical ill patients and palliative strategies. However, differences were significant in terms of the use of KL-6 and pathogen testing in urine, treatments with cyclosporine and recombinant thrombomodulin, extracorporeal membrane oxygenation in critical ill patients as well as antacid medication and anaesthesia measures as preventive methods.Conclusion: Despite the absence of recommendations, approaches to the prevention, diagnosis and treatment of AE-IPF are comparable in specialised and non-specialised ILD centres, yet certain differences in the managements of AE-IPF exist. Clinical trials and guidelines are needed to improve patient care and prognosis in AE-IPF.

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