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Medientyp: Sonstige Veröffentlichung; E-Artikel Titel: Bioorthogonal metal-free click-ligation of cRGD-pentapeptide to alginate Beteiligte: Krause, Andreas [VerfasserIn]; Kirschning, Andreas [VerfasserIn]; Dräger, Gerald [VerfasserIn] Erschienen: Cambridge : Royal Society of Chemistry, 2012 Erschienen in: Organic and Biomolecular Chemistry 10 (2012), Nr. 29 Ausgabe: published Version Sprache: Englisch DOI: https://doi.org/10.15488/2159; https://doi.org/10.1039/c2ob25604e ISSN: 1477-0520 Schlagwörter: Cyclic ; Bioactive polymers ; 1 ,3-dipolar cycloadditions ; polymer ; Cycloaddition ; Polymers ; Medical applications ; cyclic arginine glycine aspartic acid peptide ; Transition metals ; Cycloadditions ; Hexuronic Acids ; copper ; cyclic arginine-glycine-aspartic acid peptide ; Conjugation process ; glucuronic acid ; Alginates ; cyclopeptide ; Reaction progress ; hexuronic acid ; alginic acid ; ligation ; article ; chemistry ; Peptides ; [...] Entstehung: Anmerkungen: Diese Datenquelle enthält auch Bestandsnachweise, die nicht zu einem Volltext führen. Beschreibung: Click reactions have become very common and powerful ligation techniques, of which 1,3-dipolar cycloadditions have most frequently been employed. Since metal-mediated cycloadditions are incompatible in biomedical applications due to toxicity issues associated with transition metals like copper, metal-free variants provide important alternatives. The metal-free conjugation process is studied in detail with special emphasis put on the reaction progress. This report unfolds the first aqueous metal-free "click" conjugation of a cyclic RGD-pentapeptide with the biomacromolecule alginate, creating a "smart" bioactive polymer with potential applications in biomedicine. © 2012 The Royal Society of Chemistry. Zugangsstatus: Freier Zugang