HLA-DRB1*11and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis

Medientyp: E-Artikel
Titel: HLA-DRB1*11and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis
Beteiligte: Ombrello, Michael J.; Remmers, Elaine F.; Tachmazidou, Ioanna; Grom, Alexei; Foell, Dirk; Haas, Johannes-Peter; Martini, Alberto; Gattorno, Marco; Özen, Seza; Prahalad, Sampath; Zeft, Andrew S.; Bohnsack, John F.; Mellins, Elizabeth D.; Ilowite, Norman T.; Russo, Ricardo; Len, Claudio; Hilario, Maria Odete E.; Oliveira, Sheila; Yeung, Rae S. M.; Rosenberg, Alan; Wedderburn, Lucy R.; Anton, Jordi; Schwarz, Tobias; Hinks, Anne; [...]
Erschienen: Proceedings of the National Academy of Sciences, 2015
Erschienen in: Proceedings of the National Academy of Sciences
Sprache: Englisch
DOI: 10.1073/pnas.1520779112
ISSN: 0027-8424; 1091-6490
Schlagwörter: Multidisciplinary
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Beschreibung: <jats:title>Significance</jats:title><jats:p>To determine whether genetic variation within the MHC locus influences the risk of developing systemic juvenile idiopathic arthritis (sJIA), we examined a dense set of MHC region single nucleotide polymorphisms, classic HLA alleles, and the individual amino acids of HLA molecules in nine independent sJIA case-control populations. Association testing revealed that genetic variants within the MHC class II gene cluster significantly influenced sJIA risk in every study population. The strongest risk factor for sJIA was<jats:italic>HLA-DRB1*11</jats:italic>, which conferred at least a two-fold increase in disease risk in each population studied. These data implicate the interaction of antigen presenting cells with T cells in the pathogenesis of sJIA.</jats:p>
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