Synthesis of deuterium‐labeled 3‐O‐methyldopa and 4‐O‐methyldopa

Medientyp: E-Artikel
Titel: Synthesis of deuterium‐labeled 3‐O‐methyldopa and 4‐O‐methyldopa
Beteiligte: Perera, Aruna; Hyland, Keith; Nguyen, Hoa K.; Kane, Robert R.
Erschienen: Wiley, 2003
Erschienen in: Journal of Labelled Compounds and Radiopharmaceuticals
Sprache: Englisch
DOI: 10.1002/jlcr.677
ISSN: 0362-4803; 1099-1344
Schlagwörter: Organic Chemistry ; Spectroscopy ; Drug Discovery ; Radiology, Nuclear Medicine and imaging ; Biochemistry ; Analytical Chemistry
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Beschreibung: <jats:title>Abstract</jats:title><jats:p>Concise methods for the synthesis of 4‐hydroxy‐3‐[<jats:sup>2</jats:sup>H<jats:sub>3</jats:sub>]‐methoxyphenylalanine (3‐<jats:italic>O</jats:italic>‐[<jats:sup>2</jats:sup>H<jats:sub>3</jats:sub>]‐methydopa) and 3‐hydroxy‐4‐[<jats:sup>2</jats:sup>H<jats:sub>3</jats:sub>]‐methoxyphenylalanine (4‐<jats:italic>O</jats:italic>‐[<jats:sup>2</jats:sup>H<jats:sub>3</jats:sub>]‐methydopa) are described. The 3‐<jats:italic>O</jats:italic>‐[<jats:sup>2</jats:sup>H<jats:sub>3</jats:sub>]‐methydopa is a valuable internal standard for the tandem MS quantification of 3‐<jats:italic>O</jats:italic>‐methyldopa, a metabolite of value in the diagnosis of aromatic l‐amino acid decarboxylase (AADC) deficiency. Copyright © 2003 John Wiley & Sons, Ltd.</jats:p>

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