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Isobe, Masaharu; Russo, Giandomenico; Haluska, Frank G.; Croce, Carlo M.

Cloning of the Gene Encoding the δ Subunit of the Human T-Cell Receptor Reveals Its Physical Organization within the α -Subunit Locus and Its Involvement in Chromosome Translocations in T-Cell Malignancy

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  • Medientyp: E-Artikel
  • Titel: Cloning of the Gene Encoding the δ Subunit of the Human T-Cell Receptor Reveals Its Physical Organization within the α -Subunit Locus and Its Involvement in Chromosome Translocations in T-Cell Malignancy
  • Beteiligte: Isobe, Masaharu; Russo, Giandomenico; Haluska, Frank G.; Croce, Carlo M.
  • Erschienen: National Academy of Sciences of the United States of America, 1988
  • Erschienen in: Proceedings of the National Academy of Sciences of the United States of America, 85 (1988) 11, Seite 3933-3937
  • Sprache: Englisch
  • ISSN: 0027-8424
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <p>By taking advantage of ``chromosomal walking'' techniques, we have obtained clones that encompass the T-cell receptor (TCR) δ -chain gene. We analyzed clones spanning the entire J&lt;sub&gt;α&lt;/sub&gt; region extending 115 kilobases 5&lt;sup&gt;′&lt;/sup&gt; of the TCR α -chain constant region and have shown that the TCR δ -chain gene is located over 80 kilobases 5&lt;sup&gt;′&lt;/sup&gt; of C&lt;sub&gt;α&lt;/sub&gt;. TCR δ -chain gene is rearranged in the γ /δ -expressing T-cell line Peer and is deleted in α /β -expressing T-cell lines. Sequence analysis of portions of this genomic region demonstrates its identity with previously described cDNA clones corresponding to the C&lt;sub&gt;δ&lt;/sub&gt; and J&lt;sub&gt;δ&lt;/sub&gt; segments. Furthermore, we have analyzed a t(8;14)(q24;q11) chromosome translocation from a T-cell leukemia and have shown that the J&lt;sub&gt;δ&lt;/sub&gt; segment is rearranged in cells deriving from this tumor and probably directly involved in the translocation. Thus, the newly cloned TCR δ chain is implicated in the genesis of chromosome translocations in T-cell malignancies carrying cytogenetic abnormalities of band 14q11.</p>
  • Zugangsstatus: Freier Zugang